Welcome to the Guo lab at Thomas Jefferson University! We are located at the newly renovated lab space of the Department of Biochemistry and Molecular Biology.

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Liquid-liquid phase separation drives the formation of membrane-less organelles such as stress granule. Aberrant protein phase transition leads to the formation of fibrils and aggregates implicated in various neurodegenerative diseases. We are interested in understanding the molecular mechanisms underlying these aberrant phase transitions and leveraging our understanding of phase transition to develop strategies with therapeutic potential to prevent and reverse these toxic events. We use a combination of biochemistry, molecular biology, cell biology, and biophysics techniques to tackle these problems.

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We are looking for undergraduate and graduate students to join the lab, and are interested in hiring technicians and postdoctoral researchers! Please see this page for more information.

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